APP and early-onset autosomal dominant Alzheimer disease: A combination of functional pathway enrichment analysis (STRING interactions and Gene Ontology enrichment analysis (Table 4 and Supplementary Table S6) and literature searching revealed 66 proteins of particular interest (~70% of those identified as differentially regulated) as they were associated with at least one of the neuronally related GO terms of neuronal synapse, dendrite, axon, myelin sheath, actin cytoskeleton, extracellular matrix organization, IGF regulation, Alzheimer’s disease KEGG pathway or have a link to APP (Table 5).