Feeding/fasting misalignment, i.e., small breakfast or breakfast omission and higher caloric intake in the evening, e.g., in shift workers, is associated in preclinical and clinical studies with circadian clock disruption [19,22] and increased risk of developing obesity, hyperglycemia, and diabetes [16,17,18,19,20,21,22,38,39,40]. The gene discussed is CLOCK; the disease is obesity due to melanocortin 4 receptor deficiency.