AKT2 and diabetic cardiomyopathy: Furthermore, Huang et al. reported that MT overexpression in cardiomyocytes had a protective effect on diabetic cardiomyopathy in the serine/threonine-protein kinases’ Akt2 gene (Akt2)-KO mice, which was attenuated by ERK1/2 phosphorylation-regulated glucose transport and metabolism [41].