SHMT2 and gastric cancer: Since SHMT2 deficiency sensitized GC cells to hypoxia,we examined the glycolytic capacity of SGC7901 under normoxia and hypoxia using seahorse XF and found that the shSHMT2 group hada significantly lower glycolytic capacity than the shNC group at 1% oxygen (Figure 4E).These results suggested that SHMT2 deficiency caused GC cells to be more sensitive to hypoxia and significantly affected the proliferation,cell cycle, apoptosis, clone formation, and invasion and metastasis ability of the GC cells.