Similarly, HIF1α was improperly activated in the group treatedwith CoCl2 (10 μM) and SHIN1 in GC cell lines (Figure 6C).We then used LW-6 (10 μM), an inhibitor of HIF1α, to inhibit the SGC7901 cells and compared it with the SHMT2 knockdown group.The results showed that the effect of LW-6 on HIF1α expression was similar to that of the SHMT2 knockdown(Figure 6D). Here, SHMT2 is linked to gastric cancer.