SHMT2’s importance in hypoxia has been studied due to its prevalence as a non-physiological level of oxygen stress in most malignancies.Hypoxia is associated with numerous tumor hallmarks, such as cell proliferation, angiogenesis, metabolic reprogramming, and radiation resistance,and can also induce EMT and ROS phenotypes in advanced tumor cells, thus promoting cell invasion and metastasis[31,32,33]. Here, SHMT2 is linked to neoplasm.