The cell cycle analysis revealed that shSHMT2cells were more significantly inhibited in the S-phase under hypoxic conditions (Figure 4C).The FACS analysis showed that SHMT2 knockdown dramatically increased apoptosis in GC cells (MGC803, SGC7901, and HGC27) under hypoxiacompared to normoxia (Figure 4D). Here, SHMT2 is linked to gastric cancer.