SHMT2 reportedly has multiplenon-enzymatic functions, including its ability to interact with β-catenin and inhibit ubiquitination-mediated β-catenin degradation,ultimately promoting the proliferation and metastasis of colorectal cancer cells [42].Under normoxia, HIF1α binds to VHL proteins and is degraded by ubiquitination. This evidence concerns the gene VHL and colorectal cancer.