TNNI3 and heart failure: Cardiac troponin-I (cTnI), natriuretic peptides (NT-ProBNP), C-reactive protein (CRP), and soluble suppression of tumorigenicity 2 (sST2) have been used in clinical practice as human cardiovascular biomarkers to reveal the pathophysiological characteristics of heart failure, myocyte injury, ventricular wall stress, fibrosis, and cardiac remodeling [16].