EGFR and cancer: KEGG analysis revealed that key targets were mainly enriched in 9 signal pathways (Figure 10), including EGFR tyrosine kinase inhibitor resistance, the Ras signaling pathway, the Calcium signaling pathway, Adherens junction, Gap junction, Transcriptional misregulation in cancer, bladder cancer, the Adipocytokine signaling pathway and Neuroactive ligand-receptor interaction.