The same inflammatory burden was systematically reported in animal studies, with reports of NLRP3 activation in the serum of PD mice, and in human trials with elevated peripheral blood levels of NLRP3, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-1β, IL-2, IL-10, C-Reactive Protein (CRP), and Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES) in PD patients [53,66,67]. This evidence concerns the gene IL1B and Parkinson disease.