The hypothesis in which an active periodontal infection promotes the secretion of pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, TNF-α, and reactive oxygen species (ROS) and might increase the risk of PD has been proposed [104], alongside the fact that periodontal infection constitutes a new entryway for bacterial translocation in PD [54]. This evidence concerns the gene IL1B and Parkinson disease.