NR3C1 and osteosarcoma: In the context of GR and β-catenin interactions, if the interaction interface mirrors that of AR with β-catenin or the previously described GR–β-catenin interaction in osteosarcoma cells, PTMs in the DNA-binding domain (DBD; residues 421-486) may influence the interaction with help from the LBD (residues 528-777 for GR) [31,76].