Recently, 11 families with different mutations in AP1G1 were identified and all individuals show the same clinical features of a neurodevelopmental disorder (NDD) with global developmental delay and intellectual disability (ID), with severity from mild to severe [22] All these adaptinopathies show a prevalence of neurological symptoms, sometimes due to the mutation of a brain-specific isoform. The gene discussed is AP1G1; the disease is Global developmental delay.