HFD may induce depression in rats by desensitizing the Akt/GSK3β signaling pathway to 5-HT in the DG subgranular region of the hippocampal dentate gyrus, and returning to a normal diet can rescue the Akt/GSK3β response to 5-HT and alleviate depression-like behaviors [53]. Here, GSK3B is linked to major depressive disorder.