At the ex vivo level, DMF suppressed the gene expression of major cytokines involved in psoriasis (Figure 1), including IFN-γ, IL-17, and IL-22 in mononuclear cells of both psoriasis patients and healthy individuals [96], inhibiting thus the activity of TH1 and TH17 cells at the lesional skin. The gene discussed is IFNG; the disease is psoriasis.