SMAD7 and lobular neoplasia: Finally, the LN protein–protein interaction network allowed us to identify hub nodes according to confidence score: WNT3A, fibroblast growth factors (FGF2 and FGFR1), cyclins (CCND1, CCND2 and CCNE1), ACVR2A, SMAD7 and TFGB receptors (Supplementary Figure S2), which could be considered potential therapeutic targets related to the development of LN.