In addition, enrichment over-representation analysis, with GO terms and KEGG pathways, detected critical pathways implicated in inflammation, fibrosis, epithelial–mesenchymal transition and an actin cytoskeleton that identifies a handful of potential targets, such as the TGF-β superfamily (activin-A, TGFB receptors...), WNT/β-catenin and FGFs, which may be useful as therapeutic targets of renal damage in SLE. This evidence concerns the gene TGFB1 and systemic lupus erythematosus.