For miR-16-5p, previous results showed that macrophage-enriched miR-16-5p is a potential urinary biomarker of acute kidney injury in renal transplant recipients [24], and NEAT1/XIST/KCNQ1T1-miR-27a-3p/miR-16-5p-ATF3 might be a potential RNA regulatory pathway to regulate the disease progression of early diabetic nephropathy [25]. The gene discussed is ATF3; the disease is diabetic kidney disease.