In contrast to other metastasis sites, one special challenge for breast cancer cells in arriving at the brain is to cross the BBB, which can be mitigated by multiple key molecules, such as COX2, EREG, HBEGF, ITGAV, ITGB3, ST6GALNAC5, ANGPTL4, PIEZO2, and SCNN1A [34,35,37,38,39,40]. The gene discussed is ITGB3; the disease is breast carcinoma.