HBEGF and breast carcinoma: The results show that compared to both WT and SAS groups, the FAS group up-regulated COX2, EREG, HBEGF, ITGAV, ITGB3, ANGPTL4, PIEZO2, SCNN1A, and LTBP1 (9 out of 11 genes; Figure 2a), which were reported to be highly expressed in breast cancer cells with brain metastasis ability [34,35,36,37].