Macrophages affected by lactic acid can also secrete IL-6, increasing 3-phosphoinositide dependent protein kinase 1 (PDPK1)-dependent phosphoglycerate kinase (PGK1) phosphorylation by inducing PDPK1 in tumour cells, resulting in enhanced glycolysis and tumourigenesis [370]. Here, PDPK1 is linked to neoplasm.