By directly regulating decaprenyl diphosphate synthase subunit 2 (PDSS2), a mitochondrial metabolic molecule that plays a crucial role in regulating the synthesis of coenzyme Q-binding protein 10 (CoQ10), the activity of CoQ10 and mitochondrial Complex I can be increased, and the TCA cycle activity can be enhanced, thus inducing the conversion of glycolysis to mitochondrial respiration in hepatoma cells. This evidence concerns the gene PDSS2 and hepatocellular carcinoma.