Triplex-Forming Oligonucleotides (TFOs) directed against promoter regions of the ERBB2 gene can reduce ERBB2 mRNA levels by 42% and protein levels by 59% in MCF-7 cells [22], and a TFO targeting the coding region of ERBB2 has been shown to increase apoptosis and reduce tumor growth without a significant effect on HER-2 expression. This evidence concerns the gene ERBB2 and neoplasm.