For example, the associations between polyploidy and the activation of pathways of meiosis, female gametogenesis, programs of unicellularity, and signaling of multipotency (TGFbeta, JAK-STAT, c-KIT) were well documented in heart diseases, cancer, and normal tissues [79,89,134,138,139,140,141,142,143,144]. The gene discussed is TGFB1; the disease is cancer.