Proteoglycan core proteins identified included versican, which was overexpressed in AC, while perlecan, decorin, prolargin, and mimecan were underexpressed in SCLC and LCC; biglycan was underexpressed in AC, SCLC, and SqCC [24,34]. This evidence concerns the gene HSPG2 and leukoencephalopathy with calcifications and cysts.