Yadav et al. indicate that the overexpression of C-X-C chemokine receptor type 4 (CXCR-4), also known as fusin or CD184, in primary cultures of human GSCs and mouse glioma cells exhibits significant migration towards human (HBMVE) and mouse (MBMVE) brain microvascular ECs [38]. Here, CXCR4 is linked to central nervous system cancer.