Kloepper et al. reported using mice bearing orthotopic syngeneic (Gl261) GBM and human (MGG8) GBM xenografts and found that the dual blockade of Ang-2/VEGF reprogrammed the protumor M2 macrophages toward the antitumor M1 phenotype, improving the survival of GBM mice [69]. The gene discussed is VEGFA; the disease is glioblastoma.