Increased Frizzled 8 expression in K-Ras cells promoted calcium-dependent Wnt signalling, and reduced tumour sphere formation and tumour-initiating capabilities (in the K-Ras group with restored Frizzled 8 expression, 0 out of 10 recipients had developed tumour on the 36th day, but in the control K-Ras group, tumours were found in 9 out of 10 recipients). The gene discussed is FZD8; the disease is neoplasm.