IGHE and Increased total eosinophil count: Previous studies indicate that the SNPs studied (rs1420101, rs17026974, rs1921622) could act as promoters of type 2 inflammatory response in the airways, with higher serum IgE counts, high eosinophilia, and lesser FEV1 reversibility; however, their relationship to BT response has not been studied [12,13,73].