XDH and Insulin resistance: In particular, in the study of Kurajoh M et al., plasma XOR activity was found to be positively associated with the SUA level independently of other known confounding factors affecting this level, including sex differences, estimated glomerular filtration rate (eGFR), adiponectin level, visceral fat area (VFA), and homeostatic model assessment of insulin resistance (HOMA-IR) [83].