BECN1 and glioblastoma: Since autophagy has been found to contribute to GSC expansion and maintenance, we analyzed the pro-differentiative activity of JQ1 in two autophagy-defective GBM models: a genetic model represented by a GBM cell line (GL15) silenced for the autophagy upstream regulator BECLIN1 [33] and a pharmacological model using the lysosomotropic agent CQ [46].