However, in the presence of incompletely mature MDSCs after cryo-thermal therapy, the additional IL-7 did not have a significant pro-proliferative effect on CD4+ T cells, suggesting that the antitumor function of IL-7 was only evident following the reversal of immunosuppression induced by MDSCs, which could explain why the addition of IL-7 alone did not significantly improve survival of tumor-bearing mice with immunosuppressive environment [39]. This evidence concerns the gene CD4 and neoplasm.