In a study exploring the impact of emodin treatment on alleviating breast cancer cell angiogenesis, the reduced phosphorylation activation, but not expression, of RUNX2 as well as the disrupted DNA binding activity measured by ELISA were detected in MDA-MB-231 and endothelial cells upon emodin stimulation, respectively [28]. The gene discussed is RUNX2; the disease is breast carcinoma.