In mice, congenital ablation of CatSper1, CatSper2, CatSper3 or CatSper4 genes inhibits CatSper currents and sperm hyperactivation and causes infertility, although spermatogenesis and initial motility are unaffected [150,151,155,161,162,168]. The gene discussed is CATSPER2; the disease is Infertility.