Brown et al. (2016) described an infertile patient whose sperm showed deficient K+ currents but intact genes encoding SLO1 and SLO3 [132] and in pig sperm, the Kv and K2P inhibitor quinine increases progesterone-induced AR more than the specific SLO inhibitor paxilline [133]. The gene discussed is KCNMA1; the disease is Infertility.