TGFB1I1 and endometriosis: Aghajanova et al. [70] indicated that progesterone resistance in the endometrium of women with endometriosis may partly result from the impaired expression of the PGR coactivator HIC-5, of which aberrant regulation can be attributed to compromised activation of the cAMP/PKA pathway in endometriosis, resulting in impaired PGR functional activity.