Moreover, the transcriptional activity of many proinflammatory cytokines, such as IL-1, IL-6, IL-8, TNF-α, MIF, and intercellular cell adhesion molecule-1 (ICAM1), is activated by NF-κB signaling, demonstrating the key role of NF-κB in the inflammatory response in endometriosis [50]. The gene discussed is TNF; the disease is endometriosis.