INS and Insulin resistance: In high-fat-diet mice, ob/ob mice, and palmitate-, oleate-, or linoleate-treated hepatocytes, elevated levels of the lncRNA MEG3 correlated with increased G6PC, PEPCK, and foxo1 levels, which resulted in enhanced gluconeogenesis and impaired insulin-stimulated glycogen accumulation in hepatocytes, manifesting as hepatic insulin resistance [162].