MMP2 and neoplasm: However, abnormal levels of expressed MMP enzyme activity is implicated in a number of disease states, including degradation of articular cartilage in arthritis, tissue remodeling and weakening of left ventricular wall in congestive heart failure, and in tumor growth and metastasis including MMP-2, -9, and -13 [14,15,16,17,18,19], in addition to promoting tumor progression through degradation of the ECM.