As a final note, although we did not carry out a direct investigation of the impact of sex on the development of AD features, the comparison with previous reported findings in male APP/PS1 mice with the presently reported characteristics of the onset of behavioral, electrophysiological and neurochemical alteration in female APP/PS1 mice suggest the possibility of sex-related differences that are of particular relevance when considering the different incidence of AD in men and women. Here, APP is linked to Alzheimer disease.