APP and memory impairment: Instead, there was a significant increase in the magnitude of LTP when the SIRT1 inhibitor Ex-527 was present (APP/PS1+Ex-527: 74.71 ± 20.27% change over baseline, p = 0.0036 when compared to APP/PS1, n = 3–12; Figure 6C,D), implying that the role of SIRT1 may be altered in association with memory impairment, although bolstering SIRT1 activity does not recover PFC-LTP deficits in 9-month-old APP/PS1 female mice.