APP/PS1 mice spent significantly more time swimming close to walls than control mice (WT: 11.4 ± 2.4 s; APP/PS1: 29.0 ± 3.8 s; p = 0.0121, n = 4–8, Figure 2C), indicating an increased anxiety-like behavior or deficits in the choice of optimal strategies in APP/PS1 mice as compared to WT mice. This evidence concerns the gene APP and Anxiety.