APP and Alzheimer disease: Since metabolic deregulation in synapses might also account for the deterioration of synaptic plasticity and memory performance (reviewed e.g., [71]) and there is compelling evidence that metabolic set up of prefrontocortical synapses is modified in animal models of AD [72], we explored the possibility that alterations of intracellular metabolic coordinators might account for the deterioration of PFC-LTP observed in female APP/PS1 mice.