The suggestion of increased fear generalization in APP/PS1 female mice was based on the observed increased freezing during habituation in a different context (day 3; see [45]) and is in notable agreement with the higher incidence of fear-related disorders in AD patients [46] and with the suggestion that fear-based neuropsychiatric disorders may be an early marker of AD (see [47,48]). This evidence concerns the gene APP and Alzheimer disease.