In agreement, rats with a deletion of the gene encoding GAD65 (Gad2) or the gene encoding GAD67 (Gad1), leads to GABA reduction and palate deformation [122], while double GAD65/GAD67 knockout mice exhibit an increased chance of cleft palate, omphalocele and abnormal spine curvature (kyphosis) [123]. Here, GAD2 is linked to omphalocele.