More specifically, Luft et al., [25] described a high VEGF/Ang2 ratio in patients with steroid-refractory GvHD, compared to those with sensitive disease, whereas Porkholm et al., reported a correlation with the incidence of intestinal and skin/liver GvHD with the pre- and post-transplant Ang2 levels, respectively [26]. This evidence concerns the gene ANGPT2 and graft versus host disease.