In this regard, previous Authors suggested that chronic systemic inflammation related to type 2 diabetes mellitus and/or other metabolic syndromes leading to increased levels of IL-6, TNF-α, and Pentraxin 3, and decreased synthesis of IL-10 and adiponectin, may represent the link between PCOS, airway inflammation, or even asthma [15]. Here, TNF is linked to asthma.