The proteomics analysis also revealed the possibility that NME4 may be an important determinant in mitochondrial hepatopathy, and IARS hypofunction might directly contribute to the pathogenesis of fatty liver by downregulating proteins involved in hepatic lipid metabolisms, such as AK6, JAK3, LILRB3, and UBASH3B. The gene discussed is JAK3; the disease is fatty liver disease.