Tumor cells produce chemokines (CXCL2-CXC motif chemokine ligand 2), cytokines (IL-6–interleukin 6), growth factors (TGF-transforming growth factor), and platelet-derived growth factor (PDGF), thereby stimulating the transformation of normal fibroblasts into activated CAFs [12,13]. This evidence concerns the gene IL6 and neoplasm.