AKR1C3 and Marfan syndrome: We performed in silico analyses for MMP13, WNT7B, AKR1C2, AKR1C3, BMP7 AND SGCG genes on Sarcoma (TCGA, PanCancer Atlas) database including 50 UPS and 25 MFS patients and Adult Soft Tissue Sarcomas (TCGA, Cell 2017) database including 44 UPS and 17 MFS, and we found that in both studies the median mRNA expression values of MMP13 and WNT7B were higher in UPS patients compared to MFS ones, while the median values of AKR1C2, AKR1C, BMP7 and SGCG were higher in MFS patients compared to UPS ones (Figure 5 and Supplementary Figure S4).