The overexpression of the HSAT2 transcript increased the transcription of genes encoding the proteins involved in the epithelial-to-mesenchymal transition, EMT (Snail, Zeb1, Slug), and the proteins that mark mesenchymal cells with cancer-associated fibroblast phenotypes (vimentin, collagens 1A1, 11A1, and alpha-smooth muscle actin) in cancer cell lines A549 and HeLa. The gene discussed is ZEB1; the disease is cancer.