In the S. aureus keratitis study, treatment with genipin revealed a significant downregulation of IL6, TNFα, and interferon γ (IFNɣ) compared to the vehicle-treated group (p = 0.001 for IL6, p = 0.008 for TNFα, p= 0.025 for IFNɣ). Here, TNF is linked to keratitis.