In conclusion, we can speculate that the m6A modification of RPN2 mRNA by the reading protein YTHDF1 in combination with the methyltransferase METTL3 regulates the PI3K-AKT-mTOR pathway, affecting the proliferation and drug resistance of BLCA cells (Figure 4N). Here, YTHDF1 is linked to bladder transitional cell carcinoma.