In conclusion, we can speculate that the m6A modification of RPN2 mRNA by the reading protein YTHDF1 in combination with the methyltransferase METTL3 regulates the PI3K-AKT-mTOR pathway, affecting the proliferation and drug resistance of BLCA cells (Figure 4N). The gene discussed is METTL3; the disease is bladder transitional cell carcinoma.