Previous studies have shown that kaempferol activates the PI3K/Akt pathway to protect against oxidative stress in various models, such as Zearalenone-induced oxidative stress [27], isoproterenol-induced heart failure [28], and myocardial ischemia/reperfusion injury [29], by activating Nrf2. The gene discussed is AKT1; the disease is myocardial ischemia.