In the stage of iron deficiency anemia, oxygen supply to tissues is damaged, which is reflected by the reduction in hemoglobin concentration, mean corpuscular volume (MCV), MCH, serum iron, serum ferritin, TSAT, RHC, and hepcidin and the increase in sTfR, TIBC, and zinc protoporphyrin. The gene discussed is HAMP; the disease is Iron deficiency anemia.