PTH and osteoporosis: Osteoporosis in CKD patients is multifactorial and the current view includes uremic milieu, abnormalities in vitamin D metabolism, calcium and phosphorus balance, and parathyroid hormone (PTH) as well as the use of some drugs that can cause bone loss, such as glucocorticoids, vitamin K antagonists, diuretics, and proton pump inhibitors [59,65].