NFKB1 and neoplasm: Finally, a large body of literature investigated HIF-1 impact on tumorigenesis through other target genes and various biological pathways [41], including through a crosstalk with NF-kB [42,48], the regulation of pro-oncogenic miRNAs [49,50] known as targets of HIF-1, and key regulators of extracellular matrix degradation by tumor cells, leading to increased invasiveness [43].