Anti-PD-1/PD-L1 immunotherapy has proved incredibly effective in the treatment of certain cancers such as melanoma, non-small cell lung cancer, metastatic colorectal cancer, renal cell carcinoma, bladder cancer, head and neck squamous cell carcinoma, classical Hodgkin’s lymphoma, and Merkel cell carcinoma [11,12,13,14,15,16,17,18,19,20,21,22,23]. This evidence concerns the gene CD274 and cancer.