RPE65 and Leber congenital amaurosis: Fundus changes in patients with LCA were common and varied greatly [14], from relatively normal fundus due to GUCY2D variants [27], typical midperipheral changes due to SPATA7 or RPE65 variants [28,29], obvious macular atrophy due to CRB1 variants [21], to severe degeneration involving both of the retina and optic nerve due to variants in AIPL1 and NMNAT1 [30,31].