Silver wiring of vessels was also observed in the fundus of patients with variants in ACO2, NMNAT1, and IDH3A, which cause LCA and other retinal dystrophy [16,17,18], which affect the mitochondria, indicating that silver wiring or severe attenuation of vessels may be a common feature in LCA and other retinal dystrophy associated with mitochondrial dysfunction. Here, ACO2 is linked to Retinal dystrophy.