To investigate the role of LRP1 in human CHD, a large patient cohort of 1922 CHD cases from the Pediatric Cardiac Genomics Consortium (PCGC) [2] and the UPMC Children’s Hospital of Pittsburgh (CHP), plus 2602 controls from the Alzheimer’s Disease Sequencing Project (ADSP) [3] were analyzed. The gene discussed is LRP1; the disease is early-onset autosomal dominant Alzheimer disease.