(3) From the common core enrichment genes of these three pathways, seven key genes (AKT3, MAPK8, PIK3CA, PIK3R3, SOS1, SOS2, and STAT5B) were screened out, and the expression of these genes had a high correlation with both the SPAG9 expression and the OS in ccRCC (Figure 5D). Here, MAPK8 is linked to nonpapillary renal cell carcinoma.