Based on this information, we established a possible mechanism through which SPAG9 affects the prognosis of patients with ccRCC and BLCA: in ccRCC, SPAG9 promotes tumor growth but also promotes autophagy and inhibits the inflammatory response, and it has a protective effect on the whole; in BLCA, SPAG9 promotes tumor growth and leads to poor prognoses. This evidence concerns the gene SPAG9 and nonpapillary renal cell carcinoma.