(3) From the common core enrichment genes of these three pathways, seven key genes (AKT3, MAPK8, PIK3CA, PIK3R3, SOS1, SOS2, and STAT5B) were screened out, and the expression of these genes had a high correlation with both the SPAG9 expression and the OS in ccRCC (Figure 5D). The gene discussed is SPAG9; the disease is nonpapillary renal cell carcinoma.