Among the pathways listed above, the activities of the adipocytokine-signaling pathway, ERBB-signaling pathway, and JAK-STAT-signaling pathway were the most strongly correlated with the OS in the ccRCC patients, and these three pathways shared many common core enrichment genes (Figure 5B,C, Table S6). This evidence concerns the gene EGFR and nonpapillary renal cell carcinoma.