Transcription factor 7 like 2 (TCF7L2), potassium inwardly rectifying channel Subfamily J member 11 (KCNJ11), and potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) encoding genes are commonly associated with β-cell dysfunction, and a combination of insulin resistance and β-cell dysfunction can frequently result in persistent hyperglycemia [15]. The gene discussed is KCNJ11; the disease is Hyperglycemia.