CD4 and bladder transitional cell carcinoma: As presented in Figure 8A–F, except for the BLCA, in the other five kinds of cancer, low expression of COPZ1 exhibited more antitumor immune cells infiltration, including B cells, neutrophils, CD8+T cells, CD4+T cells and M1 macrophages, while high expression of COPZ1 associated with more Tregs infiltration.