Small molecules that inhibit Lysine demethylase1 (LSD1) or Lysine demethylase1 (KDM1), such as ORY-1001 and Tranylcypromine, can increase H3K4 methylation and thereby inhibit tumor suppressor genes; these drugs can be effective in treating blood malignancies and other types of cancer. Here, KDM1A is linked to cancer.