Already, Burque and coworkers noted in 2010 that the 11p15.5 ICR1 (associated with H19 and IGF2) methylation was characterized by a marked intra-placental variability, finding that a decrement in the H19/IGF2 imprinting control region placental methylation was associated with intrauterine growth restriction but not with preeclampsia [42]. The gene discussed is H19; the disease is preeclampsia.