Exome sequencing revealed that she had three rare variants in migraine genes, LRP1 c.13471G>C (p.(Asp4491His)), ECM1 c.1126T>C (p.(Cys376Arg)), and CARF c.1718C>T (p.(Ser573Phe)) [19,20,21,22]. Here, ECM1 is linked to migraine disorder.