RNF213 and migraine disorder: Furthermore, a network analysis revealed that migraine genes CTIF, APOE, LRP1, RNF213, CARF, and ECM1, musculoskeletal genes KLC2 and MYO5A, as well as LAMA2 were connected to a gene subnetwork, and some of these genes play a role in significant pathways for membrane transport, protein targeting, and coagulation (Figure 1, Table 3).